Receptor and signaling pathway involved in bovine lymphocyte activation by Atractylodis macrocephalae polysaccharides.
Identifieur interne : 000072 ( Main/Exploration ); précédent : 000071; suivant : 000073Receptor and signaling pathway involved in bovine lymphocyte activation by Atractylodis macrocephalae polysaccharides.
Auteurs : Wei Xu [République populaire de Chine] ; Sijia Fang [République populaire de Chine] ; Yong Wang [République populaire de Chine] ; Xiaoqing Chi [République populaire de Chine] ; Xiaodan Ma [République populaire de Chine] ; Tao Zhang [République populaire de Chine] ; Songhua Hu [République populaire de Chine]Source :
- Carbohydrate polymers [ 1879-1344 ] ; 2020.
Descripteurs français
- KwdFr :
- Activation des lymphocytes (effets des médicaments et des substances chimiques), Animaux (MeSH), Atractylodes (composition chimique), Biologie informatique (MeSH), Bovins (MeSH), Cytokines (biosynthèse), Lymphocytes B (effets des médicaments et des substances chimiques), Lymphocytes T (effets des médicaments et des substances chimiques), Polyosides (composition chimique), Polyosides (isolement et purification), Polyosides (pharmacologie), Propriétés de surface (MeSH), Récepteur de type Toll-4 (métabolisme), Taille de particule (MeSH), Transduction du signal (effets des médicaments et des substances chimiques).
- MESH :
- biosynthèse : Cytokines.
- composition chimique : Atractylodes, Polyosides.
- effets des médicaments et des substances chimiques : Activation des lymphocytes, Lymphocytes B, Lymphocytes T, Transduction du signal.
- isolement et purification : Polyosides.
- métabolisme : Récepteur de type Toll-4.
- pharmacologie : Polyosides.
- Animaux, Biologie informatique, Bovins, Propriétés de surface, Taille de particule.
English descriptors
- KwdEn :
- Animals (MeSH), Atractylodes (chemistry), B-Lymphocytes (drug effects), Cattle (MeSH), Computational Biology (MeSH), Cytokines (biosynthesis), Lymphocyte Activation (drug effects), Particle Size (MeSH), Polysaccharides (chemistry), Polysaccharides (isolation & purification), Polysaccharides (pharmacology), Signal Transduction (drug effects), Surface Properties (MeSH), T-Lymphocytes (drug effects), Toll-Like Receptor 4 (metabolism).
- MESH :
- chemical , biosynthesis : Cytokines.
- chemistry : Atractylodes, Polysaccharides.
- drug effects : B-Lymphocytes, Lymphocyte Activation, Signal Transduction, T-Lymphocytes.
- chemical , isolation & purification : Polysaccharides.
- chemical , metabolism : Toll-Like Receptor 4.
- chemical , pharmacology : Polysaccharides.
- Animals, Cattle, Computational Biology, Particle Size, Surface Properties.
Abstract
The present study was to investigate the molecular mechanism underlying lymphocyte activation by total polysaccharides from Atractylodis macrocephalae (RAMPtp). The results showed that RAMPtp significantly promoted the secretions of cytokines (IFN-γ, IL-1α, IL-21, IFN-α, CCL4, CXCL9 and CXCL10), increased the proportions of CD4+ and CD8+ subpopulations, and enhanced the expressions of c-JUN, NFAT4, STAT1 and STAT3. microRNA sequencing identified 67 differentially expressed miRNAs (DEMs) in RAMPtp-stimulated SMLN lymphocytes, including 55 up-regulated and 12 down-regulated. GO and KEGG enrichment analyses of the predicted DEMs-targeted genes indicated that they were associated with immune system pathways, including PI3K-Akt, MAPKs, Jak-STAT and Calcium signaling pathways, which were confirmed by western blot and pathway inhibition assays. RAMPtp was further observed to favor immunostimulatory effect on both T and B lymphocytes via binding to TCR and membrane Ig individually. These findings might explain the immunomodulatory mechanism of RAMPtp in ameliorating the bovine intramammary infection.
DOI: 10.1016/j.carbpol.2020.115906
PubMed: 32070525
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Electronic address: wyuan526@zju.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058</wicri:regionArea><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Chi, Xiaoqing" sort="Chi, Xiaoqing" uniqKey="Chi X" first="Xiaoqing" last="Chi">Xiaoqing Chi</name><affiliation wicri:level="4"><nlm:affiliation>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058, PR China. 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Electronic address: songhua@zju.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058</wicri:regionArea><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32070525</idno><idno type="pmid">32070525</idno><idno type="doi">10.1016/j.carbpol.2020.115906</idno><idno type="wicri:Area/Main/Corpus">000209</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000209</idno><idno type="wicri:Area/Main/Curation">000209</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000209</idno><idno type="wicri:Area/Main/Exploration">000209</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Receptor and signaling pathway involved in bovine lymphocyte activation by Atractylodis macrocephalae polysaccharides.</title><author><name sortKey="Xu, Wei" sort="Xu, Wei" uniqKey="Xu W" first="Wei" last="Xu">Wei Xu</name><affiliation wicri:level="4"><nlm:affiliation>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058, PR China. Electronic address: zhihong0902@zju.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058</wicri:regionArea><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Fang, Sijia" sort="Fang, Sijia" uniqKey="Fang S" first="Sijia" last="Fang">Sijia Fang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058, PR China. Electronic address: fangsj@zju.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058</wicri:regionArea><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Wang, Yong" sort="Wang, Yong" uniqKey="Wang Y" first="Yong" last="Wang">Yong Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058, PR China. Electronic address: wyuan526@zju.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058</wicri:regionArea><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Chi, Xiaoqing" sort="Chi, Xiaoqing" uniqKey="Chi X" first="Xiaoqing" last="Chi">Xiaoqing Chi</name><affiliation wicri:level="4"><nlm:affiliation>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058, PR China. Electronic address: tiffany1127@zju.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058</wicri:regionArea><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Ma, Xiaodan" sort="Ma, Xiaodan" uniqKey="Ma X" first="Xiaodan" last="Ma">Xiaodan Ma</name><affiliation wicri:level="4"><nlm:affiliation>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058, PR China. Electronic address: maxiaodan@zju.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058</wicri:regionArea><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhang, Tao" sort="Zhang, Tao" uniqKey="Zhang T" first="Tao" last="Zhang">Tao Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing, 102206, PR China. Electronic address: zhangtao@bua.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing, 102206</wicri:regionArea><wicri:noRegion>102206</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Songhua" sort="Hu, Songhua" uniqKey="Hu S" first="Songhua" last="Hu">Songhua Hu</name><affiliation wicri:level="4"><nlm:affiliation>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058, PR China. Electronic address: songhua@zju.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058</wicri:regionArea><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author></analytic><series><title level="j">Carbohydrate polymers</title><idno type="eISSN">1879-1344</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Atractylodes (chemistry)</term><term>B-Lymphocytes (drug effects)</term><term>Cattle (MeSH)</term><term>Computational Biology (MeSH)</term><term>Cytokines (biosynthesis)</term><term>Lymphocyte Activation (drug effects)</term><term>Particle Size (MeSH)</term><term>Polysaccharides (chemistry)</term><term>Polysaccharides (isolation & purification)</term><term>Polysaccharides (pharmacology)</term><term>Signal Transduction (drug effects)</term><term>Surface Properties (MeSH)</term><term>T-Lymphocytes (drug effects)</term><term>Toll-Like Receptor 4 (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes (effets des médicaments et des substances chimiques)</term><term>Animaux (MeSH)</term><term>Atractylodes (composition chimique)</term><term>Biologie informatique (MeSH)</term><term>Bovins (MeSH)</term><term>Cytokines (biosynthèse)</term><term>Lymphocytes B (effets des médicaments et des substances chimiques)</term><term>Lymphocytes T (effets des médicaments et des substances chimiques)</term><term>Polyosides (composition chimique)</term><term>Polyosides (isolement et purification)</term><term>Polyosides (pharmacologie)</term><term>Propriétés de surface (MeSH)</term><term>Récepteur de type Toll-4 (métabolisme)</term><term>Taille de particule (MeSH)</term><term>Transduction du signal (effets des médicaments et des substances chimiques)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Atractylodes</term><term>Polysaccharides</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Atractylodes</term><term>Polyosides</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>B-Lymphocytes</term><term>Lymphocyte Activation</term><term>Signal Transduction</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Activation des lymphocytes</term><term>Lymphocytes B</term><term>Lymphocytes T</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Polysaccharides</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Polyosides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Toll-Like Receptor 4</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Récepteur de type Toll-4</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Polyosides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Polysaccharides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cattle</term><term>Computational Biology</term><term>Particle Size</term><term>Surface Properties</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Biologie informatique</term><term>Bovins</term><term>Propriétés de surface</term><term>Taille de particule</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present study was to investigate the molecular mechanism underlying lymphocyte activation by total polysaccharides from Atractylodis macrocephalae (RAMPtp). The results showed that RAMPtp significantly promoted the secretions of cytokines (IFN-γ, IL-1α, IL-21, IFN-α, CCL4, CXCL9 and CXCL10), increased the proportions of CD4<sup>+</sup> and CD8<sup>+</sup> subpopulations, and enhanced the expressions of c-JUN, NFAT4, STAT1 and STAT3. microRNA sequencing identified 67 differentially expressed miRNAs (DEMs) in RAMPtp-stimulated SMLN lymphocytes, including 55 up-regulated and 12 down-regulated. GO and KEGG enrichment analyses of the predicted DEMs-targeted genes indicated that they were associated with immune system pathways, including PI3K-Akt, MAPKs, Jak-STAT and Calcium signaling pathways, which were confirmed by western blot and pathway inhibition assays. RAMPtp was further observed to favor immunostimulatory effect on both T and B lymphocytes via binding to TCR and membrane Ig individually. These findings might explain the immunomodulatory mechanism of RAMPtp in ameliorating the bovine intramammary infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32070525</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>21</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1344</ISSN><JournalIssue CitedMedium="Internet"><Volume>234</Volume><PubDate><Year>2020</Year><Month>Apr</Month><Day>15</Day></PubDate></JournalIssue><Title>Carbohydrate polymers</Title><ISOAbbreviation>Carbohydr Polym</ISOAbbreviation></Journal><ArticleTitle>Receptor and signaling pathway involved in bovine lymphocyte activation by Atractylodis macrocephalae polysaccharides.</ArticleTitle><Pagination><MedlinePgn>115906</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0144-8617(20)30080-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.carbpol.2020.115906</ELocationID><Abstract><AbstractText>The present study was to investigate the molecular mechanism underlying lymphocyte activation by total polysaccharides from Atractylodis macrocephalae (RAMPtp). The results showed that RAMPtp significantly promoted the secretions of cytokines (IFN-γ, IL-1α, IL-21, IFN-α, CCL4, CXCL9 and CXCL10), increased the proportions of CD4<sup>+</sup> and CD8<sup>+</sup> subpopulations, and enhanced the expressions of c-JUN, NFAT4, STAT1 and STAT3. microRNA sequencing identified 67 differentially expressed miRNAs (DEMs) in RAMPtp-stimulated SMLN lymphocytes, including 55 up-regulated and 12 down-regulated. GO and KEGG enrichment analyses of the predicted DEMs-targeted genes indicated that they were associated with immune system pathways, including PI3K-Akt, MAPKs, Jak-STAT and Calcium signaling pathways, which were confirmed by western blot and pathway inhibition assays. RAMPtp was further observed to favor immunostimulatory effect on both T and B lymphocytes via binding to TCR and membrane Ig individually. These findings might explain the immunomodulatory mechanism of RAMPtp in ameliorating the bovine intramammary infection.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058, PR China. Electronic address: zhihong0902@zju.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fang</LastName><ForeName>Sijia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058, PR China. Electronic address: fangsj@zju.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yong</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058, PR China. Electronic address: wyuan526@zju.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chi</LastName><ForeName>Xiaoqing</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058, PR China. Electronic address: tiffany1127@zju.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Xiaodan</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058, PR China. Electronic address: maxiaodan@zju.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Tao</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing, 102206, PR China. Electronic address: zhangtao@bua.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Songhua</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hang Zhou, 310058, PR China. Electronic address: songhua@zju.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>01</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Carbohydr Polym</MedlineTA><NlmUniqueID>8307156</NlmUniqueID><ISSNLinking>0144-8617</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011134">Polysaccharides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051197">Toll-Like Receptor 4</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D031174" MajorTopicYN="N">Atractylodes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001402" MajorTopicYN="N">B-Lymphocytes</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002417" MajorTopicYN="N">Cattle</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019295" MajorTopicYN="N">Computational Biology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008213" MajorTopicYN="N">Lymphocyte Activation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010316" MajorTopicYN="N">Particle Size</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011134" MajorTopicYN="N">Polysaccharides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013499" MajorTopicYN="N">Surface Properties</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013601" MajorTopicYN="N">T-Lymphocytes</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051197" MajorTopicYN="N">Toll-Like Receptor 4</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Atractylodis macrocephalae polysaccharides</Keyword><Keyword MajorTopicYN="N">Bovine lymphocytes</Keyword><Keyword MajorTopicYN="N">Immunomodulation</Keyword><Keyword MajorTopicYN="N">Receptor</Keyword><Keyword MajorTopicYN="N">Signaling pathway</Keyword><Keyword MajorTopicYN="N">miRNAs</Keyword></KeywordList><CoiStatement>Declaration of Competing Interest The authors declared no competing interests.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>11</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>12</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>01</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>2</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>2</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32070525</ArticleId><ArticleId IdType="pii">S0144-8617(20)30080-1</ArticleId><ArticleId IdType="doi">10.1016/j.carbpol.2020.115906</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Zhejiang</li></region><settlement><li>Hangzhou</li></settlement><orgName><li>Université de Zhejiang</li></orgName></list><tree><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Xu, Wei" sort="Xu, Wei" uniqKey="Xu W" first="Wei" last="Xu">Wei Xu</name></region><name sortKey="Chi, Xiaoqing" sort="Chi, Xiaoqing" uniqKey="Chi X" first="Xiaoqing" last="Chi">Xiaoqing Chi</name><name sortKey="Fang, Sijia" sort="Fang, Sijia" uniqKey="Fang S" first="Sijia" last="Fang">Sijia Fang</name><name sortKey="Hu, Songhua" sort="Hu, Songhua" uniqKey="Hu S" first="Songhua" last="Hu">Songhua Hu</name><name sortKey="Ma, Xiaodan" sort="Ma, Xiaodan" uniqKey="Ma X" first="Xiaodan" last="Ma">Xiaodan Ma</name><name sortKey="Wang, Yong" sort="Wang, Yong" uniqKey="Wang Y" first="Yong" last="Wang">Yong Wang</name><name sortKey="Zhang, Tao" sort="Zhang, Tao" uniqKey="Zhang T" first="Tao" last="Zhang">Tao Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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